Selection of Relevant Bacterial Strains for Novel Therapeutic Testing: a Guidance Document for Priority Cystic Fibrosis Lung Pathogens

Abstract Purpose of Review People with cystic fibrosis (CF) suffer chronic lung infections a range antimicrobial-resistant bacterial pathogens. There is an urgent need for researchers to develop novel anti-infectives treat these problematic infections, but how can we select strains which are relevant robust testing and comparative research? Recent Findings Pseudomonas aeruginosa , Burkholderia cepacia complex gladioli Mycobacterium abscessus complex, Staphylococcus aureus, Haemophilus influenza, several multidrug-resistant Gram-negative species were selected as key CF that urgently require new therapeutics. Reference isolates strain panels identified, summary the known genotypic diversity each pathogen was provided. Summary Here, summarise current resources available priority pathogens highlight systematic selection criteria use in therapeutic testing.